Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 223-224.doi: 10.3969/j.issn.1004-616x.2003.04.011

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THE CLINICAL RESEARCH OF TELOMERASE ACTIVITY I N SPUTUM OF LUNG CANCER PATIENTS

HU Jian, LI Ren-yuan, SUN Li, et al   

  1. 1.Department of Thoracic-Cardiovascular Surgery, The First Affiliated Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003, China; 2.Scientific Research Laboratory, College of Medicine, Hangzhou Normal College, Hangzhou 310012,china
  • Received:2003-01-30 Revised:2003-03-12 Online:2003-10-30 Published:2003-10-30
  • Contact: HU Jian

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Abstract: Purpose: To study the clinical significance of the expression of telomerase activity in sputa of lung cancer patients. Methods: The sputa of 30 lung cancer patients and 25 benign lung disease patients(control group) were checked for telomerase activity with PCR-TRAP ELISA. Results: The positive rates of telomerase activity in sputum was 56.7 ％(17/30) in lung cancer group and 24 ％(6 /25) in control group. The difference is statistically significant(P< 0.05). Conclusion: The detection of telomerase activity in sputum of lung cancer patient is helpful for not only the diagnosis of lung cancer but also the differential diagnosis with other benign lung diseases. The assay method is comparatively convenient and nontraumatic, and the specimen is easy to collect.

Key words: lung tumor, sputum specimen, telomerase activity